Age-Specific Control and Alzheimer Disease Reference Curves and <i>z</i> -Scores for Glial Fibrillary Acidic Protein in Blood
Our novel GFAP z-scores enable the integration and interpretation of serum GFAP levels in clinical practice, moving from the group to individual level. They support both intra- and interindividual interpretation of single GFAP levels in neurological diseases with astrocytic pathology, including an accurate discrimination of AD.
Authors
- Badrieh Fazeli (ORCID: https://orcid.org/0000-0002-2970-0065)
- Steffen Halbgebauer (ORCID: https://orcid.org/0000-0002-8711-5702)
- Veronika Klose (ORCID: https://orcid.org/0009-0004-1597-2571)
- Angela Rosenbohm (ORCID: https://orcid.org/0000-0001-9700-0338)
- Sarah Jesse (ORCID: https://orcid.org/0000-0001-6235-8145)
- Ahmed Abdelhak (ORCID: https://orcid.org/0000-0001-9731-4169)
- Gabriele Nagel (ORCID: https://orcid.org/0000-0001-6185-8535)
- Hayrettin Tumani (ORCID: https://orcid.org/0000-0002-7921-9966)
- Axel Petzold (ORCID: https://orcid.org/0000-0002-0344-9749)
- G. Bernhard Landwehrmeyer (ORCID: https://orcid.org/0000-0003-3375-790X)
- Markus Otto (ORCID: https://orcid.org/0000-0003-4273-4267)
- Dietrich Rothenbacher (ORCID: https://orcid.org/0000-0002-3563-2791)
- Franziska Bachhuber (ORCID: https://orcid.org/0000-0003-1031-9966)
- Albert C. Ludolph
Institutions
- Zimmer Biomet (Netherlands) (NL)
- University of California, San Francisco (US)
- Universität Ulm (DE)
- German Center for Neurodegenerative Diseases (DE)
- Zimmer Biomet (Germany) (DE)
- Institute of Neuroimmunology of the Slovak Academy of Sciences (SK)
- Moorfields Eye Hospital (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University Hospital in Halle (DE)
- University Hospital Ulm (DE)
- University College London (GB)
Publication Details
- Journal
- Clinical Chemistry
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1093/clinchem/hvaf120
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16