Yimusake ameliorates corporal endothelial dysfunction by down-regulating the NLRP3 inflammasome–mediated NF-κB signaling pathway and inhibiting oxidative stress
These findings demonstrate that DM exacerbates oxidative stress and endothelial damage in the corpus cavernosum through activation of the NLRP3 inflammasome-mediated NF-κB pathway, whereas Yimusake can inhibit oxidative stress and mitigate endothelial damage by downregulating this pathway, thereby facilitating the restoration of erectile tissue in rats with DMED.
Authors
- Lipan Niu (ORCID: https://orcid.org/0000-0003-3842-4960)
- Xiufang Jin
- Yulian Liu (ORCID: https://orcid.org/0009-0007-6486-689X)
- Chengxia Yang
- Fengxia Liu (ORCID: https://orcid.org/0000-0001-5164-8112)
- Rui Zhang (ORCID: https://orcid.org/0000-0002-2968-0682)
- Bingbing Zhu
- Wenfei Wang (ORCID: https://orcid.org/0000-0001-8048-724X)
Institutions
- Xinjiang Medical University (CN)
- Xinjiang Uygur Autonomous Region Disease Prevention and Control Center (CN)
- People's Hospital of Xinjiang Uygur Autonomous Region (CN)
- Xinjiang University (CN)
Publication Details
- Journal
- Sexual Medicine
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1093/sexmed/qfaf079
- Citations
- 1
- Primary Topic
- Sexual function and dysfunction studies
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Xinjiang