Antiparasitic effect of peptoids against Cryptosporidium parvum
Cryptosporidiosis, caused by <i>Cryptosporidium parvum</i>, poses significant health risks, particularly for children and immunocompromised individuals. Current treatments are ineffective in these vulnerable groups. This study explores the antiparasitic effects of peptoids against <i>C. parvum</i>. Out of 14 synthetic peptidomimetics (peptoids) screened, TM9 and TM19 exhibited potent anti-cryptosporidial activity with minimal host toxicity. These findings suggest that peptoids could be a promising new therapeutic avenue for cryptosporidiosis, warranting further investigation.
Authors
- Annelise E. Barron (ORCID: https://orcid.org/0000-0002-0735-6873)
- Rossarin Suwanarusk (ORCID: https://orcid.org/0000-0002-7310-245X)
- Morad‐Rémy Muhsin‐Sharafaldine (ORCID: https://orcid.org/0000-0002-9532-9612)
- Deborah Bow Yue Yung (ORCID: https://orcid.org/0000-0002-4086-3869)
- Daniel Pletzer (ORCID: https://orcid.org/0000-0001-5750-7505)
- Josefine Eilsø Nielsen (ORCID: https://orcid.org/0000-0001-9274-5533)
- Bruce Russell (ORCID: https://orcid.org/0000-0003-2333-4348)
- Kristian Sørensen (ORCID: https://orcid.org/0009-0000-4400-8715)
- Bridget Lamont
Institutions
- Roskilde University (DK)
- Mahidol University (TH)
- University of Otago (NZ)
- Stanford University (US)
Publication Details
- Journal
- Microbiology
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1099/mic.0.001607
- Primary Topic
- Antimicrobial Peptides and Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00