Peripheral line for vasopressor administration: Prospective multicenter observational cohort study for survival and safety
Our study found that peripheral venous catheter use for vasopressor administration in circulatory shock was associated with a low extravasation rate (1.2%), with all events occurring after more than five days, indicating it might be a safe alternative to CVC for short-term use in resource-limited settings. Findings support cautious prolonged use and consideration of central access when therapy exceeds a few days. This calls for randomized controlled trials to compare the safety and efficacy of vasopressor administration by PVC versus CVC.
Authors
- Mohammed Bedru
- Hanan Yusuf
- Sintayehu Abebe (ORCID: https://orcid.org/0000-0003-0326-9585)
- Kehabtimer Shiferaw Kotiso (ORCID: https://orcid.org/0000-0002-4195-0243)
- Andargew Yohannes Ashamo (ORCID: https://orcid.org/0000-0003-1549-3939)
- Eyob Kebede Etissa (ORCID: https://orcid.org/0000-0001-5880-3365)
- Tewodros Haile Gebremariam (ORCID: https://orcid.org/0000-0003-4704-1435)
- Adane Petros
- Addisu Melkie
- Chala Fekadu Oljira
- Dawit Kebede
- Amsalu Bekele
- Aschalew Ashagre
- Fitsum Assefa Gemechu (ORCID: https://orcid.org/0000-0001-9219-513X)
Institutions
- The Carter Center (ET)
- West Bengal Electronics Industry Development Corporation Limited (India) (IN)
- Addis Ababa University (ET)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1371/journal.pone.0333275
- Citations
- 2
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- Addis Ababa University