Reliability of blood inflammatory markers at constant real-life workloads over time: Study protocol

Knowledge of and models currently describing the pathological role of systemic inflammatory biomarkers are based on highly-controlled laboratory rat experiments. This study has the strength of assessing a human population under real-life conditions. The major challenge is in participant recruitment given the intensive and complex study design. The results of this study could provide fundamentals for initiating a cohort study and be used for developing work-related stress-recovery concepts for occupations with different physical demands to identify workers who may be at risk for developing WMSDs. German Clinical Trials Register (DRKS00031872, 25 May 2023).

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Journal
PLoS ONE
Published
2025-10-13
DOI
https://doi.org/10.1371/journal.pone.0334244
Primary Topic
Musculoskeletal pain and rehabilitation
Type
article
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article

Reliability of blood inflammatory markers at constant real-life workloads over time: Study protocol

Benjamin Steinhilber, Florestan Wagenblast, Frank Uhlemann, Thomas Läubli et al.
PLoS ONE
Musculoskeletal pain and rehabilitation
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Reliability of blood inflammatory markers at constant real-life workloads over time: Study protocol

Benjamin Steinhilber, Florestan Wagenblast, Frank Uhlemann, Thomas Läubli, Tessy Luger, Monika A. Rieger, Barbara Munz, Manfred Schmolz
article en

Abstract

Knowledge of and models currently describing the pathological role of systemic inflammatory biomarkers are based on highly-controlled laboratory rat experiments. This study has the strength of assessing a human population under real-life conditions. The major challenge is in participant recruitment given the intensive and complex study design. The results of this study could provide fundamentals for initiating a cohort study and be used for developing work-related stress-recovery concepts for occupations with different physical demands to identify workers who may be at risk for developing WMSDs. German Clinical Trials Register (DRKS00031872, 25 May 2023).

PLoS ONEVol. 20(10)
University Children's Hospital Tübingen (DE), University of Tübingen (DE)
Openalex Percentile: Top 68%
Musculoskeletal pain and rehabilitation
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