THE EFFECTIVENESS OF NANOEMULGEL OF POMELO PEEL EXTRACT (CITRUS MAXIMA) ON ANTI-ACNE IN RATTUS NORVEGICUS RATS INDUCED BY PROPIONIBACTERIUM ACNES

Acne vulgaris is a skin condition caused by chronic inflammation of the pilosebaceous follicles due to excessive oil accumulation in the skin pores. This experimental study aimed to evaluate the effectiveness of a nanoemulgel formulated with pomelo (Citrus maxima) peel extract in treating acne lesions in Rattus norvegicus rats induced with Propionibacterium acnes. The experiment involved 30 male Rattus norvegicus rats aged 12–14 weeks, weighing 150–180 grams, divided into six groups: (1) normal, (2) negative control (P. acnes induction and gel base), (3) positive control (P. acnes induction and Mediklin TR gel), (4) Treatment t1 (P. acnes induction and 2% nanoemulgel), (5) Treatment 2 (P. acnes induction and 3.5% nanoemulgel), tand (6) Treatment 3 (P. acnes induction and 5% nanoemulgel). The nanoemulgel was administered for 10 days to evaluate the healing of acne lesions ton the rats' skin. The nanoemulgel with pomelo peel extract did not show significant differences in the lesion sizes between the treatment groups.