Nanobody Immunolabelling and three-dimensional imaging reveals spatially restricted LYVE1 expression by kidney lymphatic vessels in mice
Our findings highlight a characteristic feature of kidney lymphatic vessels, whilst providing a novel experimental tool for characterisation, isolation, or perturbation of lymphatic vessels in health and disease.
Authors
- William J. Mason (ORCID: https://orcid.org/0000-0001-6014-3562)
- Lauren G. Russell (ORCID: https://orcid.org/0000-0001-8843-0176)
- E. M. Funk (ORCID: https://orcid.org/0000-0003-3376-259X)
- Ayshwarya Subramanian (ORCID: https://orcid.org/0000-0002-4134-7612)
- Sascha Ulferts (ORCID: https://orcid.org/0009-0006-3861-4966)
- René Hägerling (ORCID: https://orcid.org/0000-0002-6830-2043)
- Gideon Pomeranz (ORCID: https://orcid.org/0000-0001-9112-2924)
- David A. Long (ORCID: https://orcid.org/0000-0001-6580-3435)
- Nils Rouven Hansmeier (ORCID: https://orcid.org/0000-0001-7024-5351)
- Dale Moulding (ORCID: https://orcid.org/0000-0002-1431-7047)
- Rose Yinghan Behncke (ORCID: https://orcid.org/0009-0005-8503-3411)
- Daniyal J. Jafree (ORCID: https://orcid.org/0000-0001-8235-0394)
- Maria Kolatsi‐Joannou (ORCID: https://orcid.org/0000-0003-1636-3968)
- Laura Wilson (ORCID: https://orcid.org/0000-0003-2858-9358)
- Clàudia Abad Baucells (ORCID: https://orcid.org/0009-0006-7373-0145)
Institutions
- Cornell University (US)
- Wellcome Sanger Institute (GB)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Max Planck Institute for Molecular Genetics (DE)
- University College London (GB)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1186/s12951-025-03759-3
- Primary Topic
- Lymphatic System and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- UK Research and Innovation
- University of Oxford
- Vrije Universiteit Brussel
- Central Laser Facility, Science and Technology Facilities Council