Glucose-dependent insulin-like growth factor 1 secretion promotes breast cancer cell tumorigenesis
This study reinforces the role of IGF-1 as a potential promoter of tumor progression, suggesting that IGF-1 may act as a molecular link between elevated glucose levels and tumor growth. In a tertiary prevention context, these results could translate into improving strategies based on lifestyle changes to control blood glucose and IGF-1 levels to prevent tumor recurrence.
Authors
- Giulia Baldelli (ORCID: https://orcid.org/0000-0001-8254-2994)
- Giorgio Brandi (ORCID: https://orcid.org/0000-0003-1380-6137)
- Giosuè Annibalini (ORCID: https://orcid.org/0000-0002-6914-4905)
- Elena Barbieri (ORCID: https://orcid.org/0000-0002-3480-7983)
- Mauro De Santi (ORCID: https://orcid.org/0000-0003-2983-8344)
- A. Conti (ORCID: https://orcid.org/0000-0002-2054-7375)
- Veronica Gentilini
- Rita Emili
Institutions
- University of Urbino (IT)
- Ospedale Santa Maria (IT)
Publication Details
- Journal
- Life Sciences
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1016/j.lfs.2025.124020
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00