Exploring molecular characteristics and interactions of blood stasis syndrome in ischemic heart failure by integrated multi-omics
This multi-omics analysis reveals that immune dysregulation, inflammation, and impaired coagulation function are central to BSS in IHF. Key pathways involved include the complement and coagulation cascade as well as B-cell receptor signaling, with F2, F8, F9, and FN1 identified as potential diagnostic and therapeutic targets. These findings provide new molecular insights into BSS in IHF.
Authors
- Mingjun Zhu (ORCID: https://orcid.org/0000-0001-7646-6577)
- Jingjing Wei (ORCID: https://orcid.org/0000-0003-2020-8397)
- Qifei Zhao (ORCID: https://orcid.org/0000-0002-9808-5684)
- Rui Yu (ORCID: https://orcid.org/0000-0002-7996-814X)
- Xinfeng Zhu
- Yilin Zhang (ORCID: https://orcid.org/0009-0007-4658-0265)
- Aolong Wang
- Xinlu Wang (ORCID: https://orcid.org/0000-0002-2622-7268)
- Ming Li (ORCID: https://orcid.org/0000-0001-6291-9328)
- Lijie Qiao (ORCID: https://orcid.org/0009-0009-1573-5812)
- Bin Li (ORCID: https://orcid.org/0000-0002-8607-8874)
- Xingyuan Li (ORCID: https://orcid.org/0000-0001-9081-817X)
Institutions
- Innovation Team (China) (HK)
- First Affiliated Hospital of Henan University (CN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-10-13
- DOI
- https://doi.org/10.3389/fmolb.2025.1627849
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00