Associations Between Nicotine Metabolites and Serum Neurofilament Light Chain Levels in the General Population
These findings demonstrate robust positive associations between nicotine metabolites and sNfL levels and identify novel U-shaped associations at lower exposure levels. The results raise the hypothesis that very low nicotine metabolite levels may be associated with lower axonal injury markers, warranting further longitudinal and mechanistic studies to clarify causality.
Authors
- Jialei Yang (ORCID: https://orcid.org/0000-0002-2906-8266)
- Yunzhang Wang (ORCID: https://orcid.org/0000-0003-1165-3595)
- Yiqiang Zhan (ORCID: https://orcid.org/0000-0001-8391-2555)
- Qianqian Ji (ORCID: https://orcid.org/0009-0002-3203-4208)
- Erhan Tang
- Yueting Liao
Institutions
- Karolinska University Hospital (SE)
- Sun Yat-sen University (CN)
- Karolinska Institutet (SE)
Publication Details
- Journal
- Chronic Diseases and Translational Medicine
- Published
- 2025-10-12
- DOI
- https://doi.org/10.1002/cdt3.70024
- Primary Topic
- Nicotinic Acetylcholine Receptors Study
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sun Yat-sen University