Excess Cholesterol Biosynthesis by Up-Regulated HMGCS1 in Colorectal Cancer Cells Induced M2-Like Tumor-Associated Macrophage Polarization Via Extracellular Vesicles
Our findings revealed a mutual stimulatory effect between CRC cells and M2-like TAMs. CRC cells with hyper-expressed HMGCS1 facilitated M2-like TAM polarization by releasing cholesterol-rich EVs, and M2-like TAMs in turn promoted CRC malignancy. These findings suggest that inhibiting excessive cholesterol production may be a promising strategy for the treatment of advanced CRC.
Authors
- Tingyi Sun (ORCID: https://orcid.org/0000-0003-4448-6340)
- Shu Yang (ORCID: https://orcid.org/0000-0002-4912-777X)
- Yang Liu (ORCID: https://orcid.org/0000-0002-5058-7781)
- Xiaohui Liu
- Jian Ma (ORCID: https://orcid.org/0000-0001-8178-7666)
- Haimei Sun
- Deshan Zhou
- Bo Wu (ORCID: https://orcid.org/0009-0006-7697-2553)
Institutions
- Capital Medical University (CN)
Publication Details
- Journal
- Cancer Research and Treatment
- Published
- 2025-10-13
- DOI
- https://doi.org/10.4143/crt.2025.550
- Citations
- 3
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- National Natural Science Foundation of China