Effects of N-acetylcysteine treatment on frontal glutamate and GABA levels and associations with drinking quantity in people with co-occurring posttraumatic stress disorder and alcohol use disorder
Though preliminary, these findings are consistent with the mechanistic hypothesis that NAC reduces drinking quantity through its effects on excitatory and inhibitory neurotransmission in people with PTSD + AUD.
Authors
- James J. Prisciandaro (ORCID: https://orcid.org/0000-0002-8877-7871)
- Kevin M. Gray (ORCID: https://orcid.org/0000-0003-4503-7395)
- Sudie E. Back (ORCID: https://orcid.org/0000-0002-7683-8737)
- Jane E. Joseph (ORCID: https://orcid.org/0000-0002-8180-7206)
- Amber M. Jarnecke (ORCID: https://orcid.org/0000-0003-3815-1122)
- Elizabeth J. Santa Ana (ORCID: https://orcid.org/0000-0002-9228-0390)
Institutions
- Medical University of South Carolina (US)
- Ralph H. Johnson VA Medical Center (US)
Publication Details
- Journal
- Psychopharmacology
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1007/s00213-025-06932-6
- Citations
- 1
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.91