Reduced ocular perfusion after intravitreal Aflibercept and faricimab: an exploratory study for Tie2 receptor distribution in ophthalmic capillaries
Faricimab caused a more rapid decrease in retinal perfusion, while choroidal perfusion was equally reduced by Aflibercept and Faricimab. These different responses in the vascular systems seem to indicate a different distribution of Tie2 receptors for Angiopoietin-2. These findings warrant further investigation into the role of Tie2 receptors in the vascular response to anti-VEGF therapies.
Authors
- Leon Pomberger (ORCID: https://orcid.org/0009-0005-6715-7437)
- Martin Kallab (ORCID: https://orcid.org/0000-0002-7452-6334)
- Anna‐Sophie Reisinger (ORCID: https://orcid.org/0000-0003-2218-5897)
- Haidar Khalil (ORCID: https://orcid.org/0000-0002-0369-5237)
- Matthias Bolz (ORCID: https://orcid.org/0000-0001-8691-5276)
- Clemens Strohmaier (ORCID: https://orcid.org/0000-0001-8249-1138)
- Markus Eidherr
- Anna C. Schuhmayer
- Nina A. M. Karl
Institutions
- Johannes Kepler University of Linz (AT)
- Kepler Universitätsklinikum (AT)
Publication Details
- Journal
- Graefe s Archive for Clinical and Experimental Ophthalmology
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1007/s00417-025-06993-5
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00