PH responsive hydrogel nanocomposites for targeted Shikonin delivery enhance anti PDL1 immunotherapy in osteosarcoma
This study reveals the unique mechanism of action of Shikonin as a potential anticancer drug and demonstrates the potential of pH-responsive hydrogel nanomaterials as efficient and safe delivery systems for targeted cancer therapeutics. The strategy of Gel@PLGA@Shikonin@FA combined with atezolizumab provides a new idea and experimental basis for OS treatment.
Authors
- Mingyang Wang (ORCID: https://orcid.org/0000-0002-4076-1643)
- Xiaohong Yang
- Xiang‐Yi Chen (ORCID: https://orcid.org/0000-0001-6951-5561)
Institutions
- The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture (CN)
- Lanzhou University Second Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1007/s12672-025-03742-2
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Hubei Province