IGFBP2 plays a key role in aerobic exercise-mediated inhibition of ferroptosis in cardiac ischemia/reperfusion (I/R) injury
Aerobic exercise-induced circulating IGFBP2 directly interacts with IGF-1R, leading to increased activation of SIRT1 and reduced levels of free TXNIP, thus inhibiting cardiomyocyte ferroptosis in cardiac I/R injury.
Authors
- Youjing Sun
- Chenxi Xia (ORCID: https://orcid.org/0000-0003-1036-4222)
- Yirong Ren
- Xuyang Meng
- Yi Li (ORCID: https://orcid.org/0000-0002-6819-2462)
- Jun Wang (ORCID: https://orcid.org/0000-0002-8254-7610)
- Chenguang Yang (ORCID: https://orcid.org/0000-0001-7218-2040)
- Xiang Wang (ORCID: https://orcid.org/0009-0004-9965-6081)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Peking Union Medical College Hospital (CN)
- Peking University People's Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1186/s12967-025-06982-6
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Peking Union Medical College