Metabolic profile alterations in juvenile rats with bladder overactivity induced by short-term high-fructose intake

Short-term high-fructose intake induces OAB-like symptoms in juvenile rats, accompanied by fructose toxicity, oxidative stress, calcium ion accumulation, and activation of the CaMKK2/AMPK signaling pathway. These findings highlight a potential link between fructose metabolism and bladder dysfunction, offering new insights for exploring metabolic or antioxidant-based therapeutic strategies in pediatric OAB.