A Multicenter Data Comprehensive Analysis of Rehabilitation Strategies for COVID-19 Sequelae: Current Status, Challenges, and Future Perspectives

The COVID-19 pandemic has led to a substantial proportion of survivors experiencing persistent, multisystem sequelae, encompassing respiratory dysfunction, neuromuscular impairments, cardiovascular complications, and psychological disorders. These heterogeneous and complex late effects pose significant challenges for rehabilitation professionals in conducting comprehensive assessments and designing tailored interventions. This review integrates data from multicenter studies to elucidate the clinical manifestations of COVID-19 sequelae, evaluate the validity and reliability of existing assessment instruments, and examine the efficacy of diverse rehabilitation modalities. Emphasis is placed on the pivotal role of multidisciplinary teams, the feasibility of tele-rehabilitation platforms, and the incorporation of innovative technologies—such as virtual reality, wearable sensors, and artificial intelligence—in optimizing rehabilitation outcomes. By systematically analyzing rehabilitation pathways across different sequelae, this paper aims to furnish evidence-based recommendations to refine clinical protocols, enhance the efficiency of rehabilitation services, and ultimately facilitate functional recovery and quality-of-life improvements for individuals affected by long COVID.