A gene-expression signature defines a subtype of Stomach Adenocarcinomas with low levels of Claudins and a high ratio of NF-YA long/NF-YA short splicing variants
Our work supports the notion that three overlapping features-low expression of Claudin-3/4/7, high NF-YA long/NF-YA short ratio and a 158-gene signature-mark a specific subset of STAD characterized by mesenchymal features and poor prognosis.
Authors
- Alberto Gallo (ORCID: https://orcid.org/0000-0002-2188-1324)
- Roberto Mantovani (ORCID: https://orcid.org/0000-0002-1919-0559)
- Diletta Dolfini (ORCID: https://orcid.org/0000-0002-5346-6096)
- Mirko Ronzio (ORCID: https://orcid.org/0000-0002-4699-4405)
- Enrico Garattini (ORCID: https://orcid.org/0000-0001-8983-886X)
- Monica Campbell
- Sofia Polettini (ORCID: https://orcid.org/0009-0005-9299-5686)
Institutions
- University of Milan (IT)
- Mario Negri Institute for Pharmacological Research (IT)
Publication Details
- Journal
- Gastric Cancer
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1007/s10120-025-01671-1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00