Beyond Gastroenteritis: A Case of Salmonella Infection Leading to Adrenal Insufficiency

Primary adrenal insufficiency (PAI), or Addison's disease, is a rare and potentially life-threatening condition that requires prompt diagnosis and management. While most cases are autoimmune, other causes include infections such as <i>Salmonella</i>, though this is rarely reported. We describe a case of bilateral adrenal abscesses and adrenal insufficiency secondary to disseminated <i>Salmonella</i> Saintpaul infection in a previously healthy 20-year-old male following travel to Thailand. This case highlights the importance of early recognition of adrenal involvement in septic patients with persistent fever and electrolyte imbalances, even in immunocompetent individuals.

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Journal
Cureus
Published
2025-10-13
DOI
https://doi.org/10.7759/cureus.94443
Primary Topic
Adrenal Hormones and Disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

Beyond Gastroenteritis: A Case of Salmonella Infection Leading to Adrenal Insufficiency

Aye C. Paing, Kyaw Thura, Clare Pollard, Aye Pyae Tin Hla et al.
Cureus
Adrenal Hormones and Disorders
article

Beyond Gastroenteritis: A Case of Salmonella Infection Leading to Adrenal Insufficiency

Aye C. Paing, Kyaw Thura, Clare Pollard, Aye Pyae Tin Hla, Thwe Thwe Wint Htal
article en

Abstract

Primary adrenal insufficiency (PAI), or Addison's disease, is a rare and potentially life-threatening condition that requires prompt diagnosis and management. While most cases are autoimmune, other causes include infections such as <i>Salmonella</i>, though this is rarely reported. We describe a case of bilateral adrenal abscesses and adrenal insufficiency secondary to disseminated <i>Salmonella</i> Saintpaul infection in a previously healthy 20-year-old male following travel to Thailand. This case highlights the importance of early recognition of adrenal involvement in septic patients with persistent fever and electrolyte imbalances, even in immunocompetent individuals.

CureusVol. 17(10)
Glan Clwyd Hospital (GB), West Middlesex University Hospital (GB), Warwick Hospital (GB), Victoria Hospital (GB), Victoria Hospital (IN), South Warwickshire NHS Foundation Trust (GB)
Openalex Percentile: Top 62%
Adrenal Hormones and Disorders
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