Treatment of glioblastoma with tumor-specific amplitude-modulated radiofrequency electromagnetic fields

This is the first report showing <i>in vitro</i> antitumor activity, disruption of the mitotic spindle, activation of the Mitotic Roles of Polo-like kinase pathway in GB. This is also the first report showing feasibility and clinical activity in patients with brain tumor.

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Publication Details

Journal
Oncotarget
Published
2025-10-13
DOI
https://doi.org/10.18632/oncotarget.28770
Primary Topic
Microtubule and mitosis dynamics
Type
article
Field-Weighted Citation Impact
0.00

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article

Treatment of glioblastoma with tumor-specific amplitude-modulated radiofrequency electromagnetic fields

Christopher T. Whitlow, Alexandre Barbault, Glenn Jay Lesser, Allan M. Johansen et al.
Oncotarget
Microtubule and mitosis dynamics
article

Treatment of glioblastoma with tumor-specific amplitude-modulated radiofrequency electromagnetic fields

Christopher T. Whitlow, Alexandre Barbault, Glenn Jay Lesser, Allan M. Johansen, Callum McGrath, S.C. Lester, Geoffrey Barger, Sambad Sharma, Lance David Miller, Asfar S. Azmi, Ralph B. D’Agostino, Jason Tang, Preeya F. Achari, Boris Pasche, Kojo Agyemang, Michael D. Chan, Waldemar Debinski, Kimberly Sheffield, Liyue Zhang, Michael J. Pennison, Denise M. Gibo, Hugo Jimenez, Minghui Wang, Annette J. Johnson, Kounosuke Watabe, Janaka Liyanage
article en

Abstract

This is the first report showing <i>in vitro</i> antitumor activity, disruption of the mitotic spindle, activation of the Mitotic Roles of Polo-like kinase pathway in GB. This is also the first report showing feasibility and clinical activity in patients with brain tumor.

OncotargetVol. 16(1)
Atrium Health Wake Forest Baptist (US), Wayne State University (US), Augusta University (US), The Barbara Ann Karmanos Cancer Institute (US), Wake Forest University (US)
Wayne State University, Comprehensive Cancer Center at Wake Forest Baptist Medical Center, Barbara Ann Karmanos Cancer Institute, National Institutes of Health, National Cancer Institute
Openalex Percentile: Top 70%
Microtubule and mitosis dynamics
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