Treatment of glioblastoma with tumor-specific amplitude-modulated radiofrequency electromagnetic fields
This is the first report showing <i>in vitro</i> antitumor activity, disruption of the mitotic spindle, activation of the Mitotic Roles of Polo-like kinase pathway in GB. This is also the first report showing feasibility and clinical activity in patients with brain tumor.
Authors
- Christopher T. Whitlow (ORCID: https://orcid.org/0000-0003-2392-8293)
- Alexandre Barbault
- Glenn Jay Lesser (ORCID: https://orcid.org/0009-0003-5471-8907)
- Allan M. Johansen (ORCID: https://orcid.org/0000-0002-2896-1749)
- Callum McGrath (ORCID: https://orcid.org/0009-0003-1509-5997)
- S.C. Lester
- Geoffrey Barger
- Sambad Sharma (ORCID: https://orcid.org/0000-0001-5184-8624)
- Lance David Miller (ORCID: https://orcid.org/0000-0003-3799-2528)
- Asfar S. Azmi (ORCID: https://orcid.org/0000-0003-1178-9505)
- Ralph B. D’Agostino (ORCID: https://orcid.org/0000-0002-3550-8395)
- Jason Tang
- Preeya F. Achari
- Boris Pasche (ORCID: https://orcid.org/0000-0002-3750-7898)
- Kojo Agyemang (ORCID: https://orcid.org/0000-0001-8841-4483)
- Michael D. Chan (ORCID: https://orcid.org/0000-0002-5278-6709)
- Waldemar Debinski
- Kimberly Sheffield (ORCID: https://orcid.org/0000-0001-7664-0336)
- Liyue Zhang (ORCID: https://orcid.org/0000-0001-6679-4411)
- Michael J. Pennison (ORCID: https://orcid.org/0000-0002-1384-5091)
- Denise M. Gibo
- Hugo Jimenez (ORCID: https://orcid.org/0000-0002-4234-7075)
- Minghui Wang (ORCID: https://orcid.org/0000-0003-3644-7325)
- Annette J. Johnson
- Kounosuke Watabe
- Janaka Liyanage
Institutions
- Atrium Health Wake Forest Baptist (US)
- Wayne State University (US)
- Augusta University (US)
- The Barbara Ann Karmanos Cancer Institute (US)
- Wake Forest University (US)
Publication Details
- Journal
- Oncotarget
- Published
- 2025-10-13
- DOI
- https://doi.org/10.18632/oncotarget.28770
- Primary Topic
- Microtubule and mitosis dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wayne State University
- Comprehensive Cancer Center at Wake Forest Baptist Medical Center
- Barbara Ann Karmanos Cancer Institute
- National Institutes of Health
- National Cancer Institute