Dual redox effects of 2,6-bis-(4-hydroxyl-3-methoxybenzylidene) cyclohexanone (BHMC) on human liver cancer cells, HepG2 via ROS, glutathione and Nrf2/Keap1 pathway
BHMC exhibits potent antioxidant activity by reducing harmful reactive oxygen species and boosting protective glutathione levels in cells at low doses, but at higher doses, it may induce oxidative stress. These findings suggest BHMC's dose-dependent role in balancing antioxidant and pro-oxidant effects, highlighting its potential for further therapeutic exploration.
Authors
- Armania Nurdin (ORCID: https://orcid.org/0000-0002-4773-6854)
- Nurliyana Najwa Md Razip (ORCID: https://orcid.org/0000-0002-8565-5609)
- Sharifah Sakinah Syed Alwi (ORCID: https://orcid.org/0000-0002-6497-706X)
- Zulkefley Othman (ORCID: https://orcid.org/0000-0001-6973-0747)
- Mojtaba Shafiee (ORCID: https://orcid.org/0000-0002-6306-1527)
Institutions
- Universiti Putra Malaysia (MY)
Publication Details
- Journal
- Scientific Reports
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1038/s41598-025-19874-y
- Citations
- 2
- Primary Topic
- Curcumin's Biomedical Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.18
Funders
- Universiti Putra Malaysia