Quantitative terbium-161 SPECT/CT imaging: demonstrating the feasibility of image-based dosimetry and highlighting pitfalls
This study demonstrates that highly accurate SPECT/CT-based <sup>161</sup>Tb quantification is feasible, further cementing <sup>161</sup>Tb as a viable theragnostic alternative. A MEGP collimator, a 75 keV window, and a CF derived from a homogeneous cylinder measurement appears preferable. The 49 keV window could be useful at late imaging time points, given its high sensitivity, if further optimized. Degradation from penetration and subsequent downscatter may be mitigated with a more refined reconstruction. Further investigations into dead-time effects are encouraged.
Authors
- Nicholas Philip van der Meulen (ORCID: https://orcid.org/0000-0001-6077-5594)
- Frida Westerbergh (ORCID: https://orcid.org/0009-0006-3704-7357)
- Philipp Ritt
- Andreas Grings
- Peter Bernhardt (ORCID: https://orcid.org/0000-0003-1984-4353)
- Cristina Müller (ORCID: https://orcid.org/0000-0001-9357-9688)
Institutions
- Sahlgrenska University Hospital (SE)
- Paul Scherrer Institute (CH)
- ETH Zurich (CH)
- Universitätsklinikum Erlangen (DE)
- Isotopen Technologien München (Germany) (DE)
- University of Gothenburg (SE)
Publication Details
- Journal
- EJNMMI Research
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1186/s13550-025-01326-3
- Citations
- 1
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- Cancerfonden
- Vetenskapsrådet
- Göteborgs Universitet