Prior knowledge on context-driven DNA fragmentation probabilities can improve de novo genome assembly algorithms
This work could lay the groundwork for future enhanced de novo genome assembly algorithms, with improved ability to effectively assemble and evaluate ultrashort DNA fragments relevant for cell-free, ancient, and forensic DNA research.
Authors
- Patrick Pflughaupt (ORCID: https://orcid.org/0000-0002-0847-6391)
- Aleksandr B. Sahakyan (ORCID: https://orcid.org/0000-0002-8343-3594)
Institutions
- MRC Weatherall Institute of Molecular Medicine (GB)
Publication Details
- Journal
- BMC Bioinformatics
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1186/s12859-025-06267-1
- Primary Topic
- Genomics and Phylogenetic Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Medical Research Council
- Clarendon Fund