Antitumor Effect of Selumetinib for Brainstem Glioma in an Adult With NF1: A Case Report
Primary treatment with MAPK kinase inhibitors can lead to tumor regression in brainstem glioma in an adult patient with NF1. We recommend that patients with brainstem glioma undergo biopsy and mutation testing, especially those with an unusually aggressive clinical course.
Authors
- Hideyuki Yoshioka (ORCID: https://orcid.org/0000-0002-6469-7156)
- Mitsuto Hanihara (ORCID: https://orcid.org/0000-0002-7621-6102)
- Megumu Fujihara
- Kunio Mochizuki (ORCID: https://orcid.org/0000-0001-9577-0320)
- Hirofumi Kazama
- Ryu Saito
- Hiroyuki Kinouchi (ORCID: https://orcid.org/0000-0003-0841-5502)
- Yoshinori Muto (ORCID: https://orcid.org/0000-0002-7757-0226)
- Takashi Okamoto (ORCID: https://orcid.org/0000-0002-1228-603X)
Institutions
- University of Yamanashi Hospital (JP)
- University of Yamanashi (JP)
Publication Details
- Journal
- Neurosurgery Open
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1227/neuprac.0000000000000175
- Primary Topic
- Neurofibromatosis and Schwannoma Cases
- Type
- article
- Field-Weighted Citation Impact
- 0.00