Fatal outcome of severe serotonin syndrome and acute respiratory distress syndrome after self-poisoning with paroxetine: a case report
Our case illustrates the importance of early and aggressive intervention, while highlighting the limited efficacy of currently available extracorporeal elimination techniques in severe paroxetine overdose. Given the protracted and progressive symptoms observed in this case report and others, clinicians should remain vigilant for pharmacokinetic complications such as pharmacobezoars or poor CYP2D6 metabolism in massive selective serotonin reuptake inhibitor overdose, leading to an early and aggressive treatment in similar cases with serotonin syndrome.
Authors
- Marie Anne‐Catherine Neumann (ORCID: https://orcid.org/0000-0002-2396-6110)
- Christoph Hüser (ORCID: https://orcid.org/0000-0002-6112-4678)
- Jan‐Hendrik Naendrup (ORCID: https://orcid.org/0000-0002-6420-7938)
- Sina M. Hopff (ORCID: https://orcid.org/0000-0002-8886-4596)
- Boris Böll (ORCID: https://orcid.org/0000-0002-6432-0981)
- Dennis A. Eichenauer (ORCID: https://orcid.org/0000-0002-1927-3514)
- Oezguer A. Onur (ORCID: https://orcid.org/0000-0001-8336-7075)
- Alexander F. vom Stein (ORCID: https://orcid.org/0000-0002-6910-7792)
- Nathalie Schmidt (ORCID: https://orcid.org/0000-0002-9841-8418)
- David Steindl
Institutions
- University of Cologne (DE)
- Düsseldorf University Hospital (DE)
- Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE)
- University Hospital Cologne (DE)
- Heinrich Heine University Düsseldorf (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Journal of Medical Case Reports
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1186/s13256-025-05602-7
- Citations
- 1
- Primary Topic
- Electroconvulsive Therapy Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.47