A generative adversarial optimization strategy for predicting counterfactual trajectories of grey matter atrophy

This study introduces a novel counterfactual generation method that provides interpretable, anatomically grounded explanations of MS progression. The framework serves as a powerful tool for hypothesis generation and model validation in biomedical imaging studies, particularly where understanding disease mechanisms is crucial.

Authors

Berardino Barile (ORCID: https://orcid.org/0000-0002-4016-9172)
Dominique Sappey‐Marinier (ORCID: https://orcid.org/0000-0003-4104-1514)
Thomas Grenier (ORCID: https://orcid.org/0000-0002-3630-5856)
Enyi Chen

Institutions

Université Claude Bernard Lyon 1 (FR)
Centre National de la Recherche Scientifique (FR)
Inserm (FR)
Institut National des Sciences Appliquées de Lyon (FR)
McGill University (CA)

Publication Details

Journal: Computer Methods and Programs in Biomedicine
Published: 2025-10-13
DOI: https://doi.org/10.1016/j.cmpb.2025.109095
Primary Topic: Functional Brain Connectivity Studies
Type: article
Field-Weighted Citation Impact: 0.00

Controls

|||

ALL TIME

JAN

FEB

MAR

APR

MAY

JUN

JUL

AUG

SEP

OCT

article

A generative adversarial optimization strategy for predicting counterfactual trajectories of grey matter atrophy

Berardino Barile, Dominique Sappey‐Marinier, Thomas Grenier, Enyi Chen

Oct 13, 2025

Computer Methods and Programs in Biomedicine

Functional Brain Connectivity Studies

article

A generative adversarial optimization strategy for predicting counterfactual trajectories of grey matter atrophy

Berardino Barile, Dominique Sappey‐Marinier, Thomas Grenier, Enyi Chen

October 13, 2025article en

Abstract

This study introduces a novel counterfactual generation method that provides interpretable, anatomically grounded explanations of MS progression. The framework serves as a powerful tool for hypothesis generation and model validation in biomedical imaging studies, particularly where understanding disease mechanisms is crucial.

Computer Methods and Programs in BiomedicineVol. 273

Université Claude Bernard Lyon 1 (FR), Centre National de la Recherche Scientifique (FR), Inserm (FR), Institut National des Sciences Appliquées de Lyon (FR), McGill University (CA)

Openalex Percentile: Top 71%

Functional Brain Connectivity Studies

DOI Open Access PDF OpenAlex

AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

A generative adversarial optimization strategy for predicting counterfactual trajectories of grey matter atrophy — Berardino Barile, Dominique Sappey‐Marinier, et al. · Computer Methods and Programs in Biomedicine (2025) | TGRS Research Map | TGRS