Case Report: Successful Drug Desensitization to Ustekinumab in an Adult Patient with Crohn’s Disease

Objective: Ustekinumab is a biological agent used in the treatment of inflammatory diseases. Since biological therapies are targeted therapies, their use is increasing and the incidence of related reactions is increasing accordingly. We present this case because of the successful desensitization we applied to a patient who developed a reaction to ustekinumab. Materials and methods: An adult Crohn's disease patient who experienced an adverse reaction to the fifth subcutaneous dose of ustekinumab was evaluated in our Immunology and Allergy clinic. Results: The patient was successfully treated using the stepwise rapid drug desensitization protocol. Conclusion: We present this case to emphasize the importance and awareness of desensitization in managing drug reactions in clinics such as Dermatology, Rheumatology and Gastroenterology where the drug is widely used.