Simultaneous Durvalumab and Platinum-Based Chemoradiotherapy in Unresectable Stage III Non–Small Cell Lung Cancer: The Phase III PACIFIC-2 Study
Among patients with unresectable stage III NSCLC, durvalumab administered from the start of cCRT failed to demonstrate additional benefit compared with cCRT plus placebo. Consolidation durvalumab following definitive cCRT remains the standard of care in this setting.
Authors
- Fernanda Maris Peria (ORCID: https://orcid.org/0000-0001-5133-165X)
- Zsuzsanna Szalai (ORCID: https://orcid.org/0000-0001-7012-2060)
- Lyubov Vladimirova
- Natalia Fadeeva (ORCID: https://orcid.org/0000-0003-3923-929X)
- Joseph Parra
- Nguyễn Đình Tiến (ORCID: https://orcid.org/0000-0002-2215-0830)
- Bogdan Żurawski
- В. В. Бредер (ORCID: https://orcid.org/0000-0002-6244-4294)
- Shailesh Bondarde
- Ibolya Laczó
- Janusz Limon (ORCID: https://orcid.org/0009-0003-8032-5859)
- Ana Caroline Zimmer Gelatti (ORCID: https://orcid.org/0000-0002-5939-8071)
- Alejandro Molina Alavez
- Manuel Magallanes Maciel
- Galina Statsenko (ORCID: https://orcid.org/0000-0001-7123-8639)
- Pedro De Marchi (ORCID: https://orcid.org/0000-0001-5259-0215)
- Mustafa Özgüroğlu (ORCID: https://orcid.org/0000-0002-8417-8628)
- Teppei Yamaguchi (ORCID: https://orcid.org/0000-0002-8909-5709)
- Froylán López-López
- Keunchil Park (ORCID: https://orcid.org/0000-0002-4846-7449)
- Huyen Thi Phung (ORCID: https://orcid.org/0000-0002-9509-1050)
- Alejandro Figueroa
- Jeffrey D. Bradley (ORCID: https://orcid.org/0000-0001-9305-7396)
- Teresa T. Sy Ortin (ORCID: https://orcid.org/0000-0001-8514-0106)
- Hidetoshi Hayashi (ORCID: https://orcid.org/0000-0001-8787-5587)
- Gyeong‐Won Lee (ORCID: https://orcid.org/0000-0002-1781-2262)
- Thaís Gomes de Almeida (ORCID: https://orcid.org/0000-0001-5607-3039)
- Tetsuro Kondo (ORCID: https://orcid.org/0000-0003-4388-4814)
- Henry Gómez (ORCID: https://orcid.org/0000-0002-3415-9701)
- Yuichi Sakamori (ORCID: https://orcid.org/0000-0001-6421-7266)
- Sang‐We Kim (ORCID: https://orcid.org/0000-0003-1065-8095)
- Adilson Faccio
- Sewanti Limaye (ORCID: https://orcid.org/0000-0002-2170-5187)
- J. Gomez Rangel
- Mustafa Erman (ORCID: https://orcid.org/0000-0001-5884-4669)
- Chiara Villa (ORCID: https://orcid.org/0000-0001-6245-4487)
- Ewa Wasilewska-Teśluk (ORCID: https://orcid.org/0000-0002-3083-6410)
- Jaromı́r Roubec
- Sarayut Lucien Geater (ORCID: https://orcid.org/0000-0002-3494-8268)
- Natalia Valdiviezo (ORCID: https://orcid.org/0000-0002-4300-5958)
- György Losonczy (ORCID: https://orcid.org/0000-0002-0211-5237)
- Rafał Dziadziuszko (ORCID: https://orcid.org/0000-0001-8080-9843)
- Jerry Tan Chun Bing
- Virote Sriuranpong (ORCID: https://orcid.org/0000-0001-8787-5026)
- Mikhail Dvorkin
- Gustavo Girotto (ORCID: https://orcid.org/0000-0002-4098-1320)
- Andrea Fülöp
- Nguyen Khoi Quan (ORCID: https://orcid.org/0000-0002-3222-0978)
- Hari Om Goyal
- A. Badzio
- Tuncay Göksel (ORCID: https://orcid.org/0000-0002-6089-1840)
- Kaplan Ma (ORCID: https://orcid.org/0000-0003-0882-0524)
- Gabriella Gálffy (ORCID: https://orcid.org/0000-0001-7255-035X)
- Dariusz M. Kowalski (ORCID: https://orcid.org/0000-0002-9452-3229)
- Kartikeya Jain
- Hasan Şenol Çoşkun (ORCID: https://orcid.org/0000-0003-2969-7561)
- Marie Grace Dawn Isidro (ORCID: https://orcid.org/0000-0002-8628-175X)
- Nirav Asarawala
- Michael Newton (ORCID: https://orcid.org/0000-0003-1649-4116)
- Gustavo Sanches Faria Pinto
- К. К. Лактионов (ORCID: https://orcid.org/0000-0003-4469-502X)
- J.A. Alatorre Alexander
- Makoto Nishio (ORCID: https://orcid.org/0000-0003-4969-4165)
- Juliana de Menezes
- Zofia F. Bielecka (ORCID: https://orcid.org/0000-0002-1454-5437)
- Ondřej Bílek (ORCID: https://orcid.org/0000-0001-9581-3423)
- Gilberto de Castro (ORCID: https://orcid.org/0000-0001-8765-3044)
- Toyoaki Hida (ORCID: https://orcid.org/0000-0003-3537-0020)
- Sushant Mittal
- Siriwimon Saichamchan
- Lê Tuấn Anh (ORCID: https://orcid.org/0000-0001-9169-7453)
- Milada Zemanová (ORCID: https://orcid.org/0000-0002-1904-1035)
- Evgeniy Levchenko (ORCID: https://orcid.org/0000-0003-1376-6286)
- Alexander Arkhipov
- Eduardo Silva (ORCID: https://orcid.org/0000-0001-7166-3459)
- Dong‐Wan Kim (ORCID: https://orcid.org/0000-0001-5124-7132)
- Kaoru Kubota (ORCID: https://orcid.org/0000-0003-0367-2606)
- Nan Jia (ORCID: https://orcid.org/0000-0003-1952-5803)
- Sankar Srinivasan
- Jarin Chindaprasirt (ORCID: https://orcid.org/0000-0001-8367-0365)
- Young Hak Kim (ORCID: https://orcid.org/0000-0003-0541-1020)
- Sérgio de Azevedo (ORCID: https://orcid.org/0000-0002-4266-2120)
- Ekaterina Solovyeva
- Manuel Leiva
- Busyamas Chewaskulyong
- Vanessa Bermudez
- Barbara Domingo
- Isamu Okamoto
- Sung Sook Lee
- Satheesh Chiradoni Thungappa
- Yeni Nerón
- J. Menezes (ORCID: https://orcid.org/0000-0002-5981-2324)
- R Krishnappa
- Pratibha Chander
- Mohamed Sehran
- Paolo Valdez
- Annielyn Beryl Cornel
Institutions
- Ankara University (TR)
- Charles University (CZ)
- King Chulalongkorn Memorial Hospital (TH)
- Istanbul University-Cerrahpaşa (TR)
- Hospital Nossa Senhora da Conceição (BR)
- AstraZeneca (Japan) (JP)
- AstraZeneca (Poland) (PL)
- Hospital São Lucas da PUCRS (BR)
- AstraZeneca (United States) (US)
- Chungbuk National University Hospital (KR)
- Országos Korányi Tbc és Pulmonológiai Intézet (HU)
- Sendai Kousei Hospital (JP)
- University of Pennsylvania (US)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1200/jco-25-00036
- Citations
- 16
- Primary Topic
- Lung Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 24.29