Generalized pustular psoriasis treated with additional biologics after spesolimab: a case series from Japan
This case series from Japan describes three patients with generalized pustular psoriasis who required additional biologic therapies after initial treatment with spesolimab because of persistent erythematous lesions. While spesolimab rapidly resolved pustules and systemic symptoms, complete disease control could not be achieved with acute-phase spesolimab treatment alone, underscoring the need for further data on long-term management strategies.
Authors
- Yasuhiro Fujisawa (ORCID: https://orcid.org/0000-0003-3010-8496)
- Ken Shiraishi (ORCID: https://orcid.org/0000-0002-1153-7749)
- Jun Muto (ORCID: https://orcid.org/0000-0001-8493-4051)
- Kazuki Yatsuzuka (ORCID: https://orcid.org/0000-0001-7747-0551)
- Kazuhide Nishihara (ORCID: https://orcid.org/0000-0001-8418-3403)
- Nobushige Kohri (ORCID: https://orcid.org/0009-0009-0269-2542)
- Chiaki Sasaki
- Satoshi Yoshida (ORCID: https://orcid.org/0000-0003-3945-4459)
Institutions
- Ehime University (JP)
Publication Details
- Journal
- Clinical and Experimental Dermatology
- Published
- 2025-10-11
- DOI
- https://doi.org/10.1093/ced/llaf457
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00