Updated guidelines in the treatment of myeloma bone disease in 2025: consensus statement by the Medical and Scientific Advisory Group of Australia (MSAG) to Myeloma Australia
This updated guideline recommends a two-year course of bisphosphonate treatment, with suggested extension of dosing intervals if the disease remains stable. Denosumab, a monoclonal antibody targeting receptor activator of nuclear factor ϰB ligand (RANKL), has demonstrated efficacy and non-inferiority compared to zoledronic acid in the treatment of MBD and may serve as an alternative treatment option especially with renal impairment. Further research into the utility of bone turnover markers for guiding anti-resorptive therapy in myeloma bone disease may provide significant clinical benefit. In addition, therapeutic strategies aimed at enhancing osteoblastic activity represent a potential therapeutic strategy.
Authors
- Phoebe Joy Ho
- Cindy Lee (ORCID: https://orcid.org/0000-0002-1893-961X)
- Ferenc Szabó (ORCID: https://orcid.org/0000-0001-7273-6736)
- Henry Miles Prince (ORCID: https://orcid.org/0000-0002-0058-2448)
- Georgia J. B. McCaughan (ORCID: https://orcid.org/0000-0002-4838-9022)
- Dipti Talaulikar (ORCID: https://orcid.org/0000-0001-6766-8345)
- Angelina Yong
- Kate Vandyke (ORCID: https://orcid.org/0000-0002-1033-849X)
- Hang Quach (ORCID: https://orcid.org/0000-0002-4796-3352)
- Simon James Harrison (ORCID: https://orcid.org/0000-0003-4555-6582)
- Bradley Augustson
Institutions
- Australian National University (AU)
- The University of Sydney (AU)
- St. Vincent's Birmingham (US)
- Royal Adelaide Hospital (AU)
- The University of Melbourne (AU)
- University of South Australia (AU)
- Royal Prince Alfred Hospital (AU)
- Peter MacCallum Cancer Centre (AU)
- Sir Charles Gairdner Hospital (AU)
- St Vincent's Hospital Melbourne (AU)
- Saint Vincent's Catholic Medical Center (US)
- The Catholic University of Korea St. Vincent's Hospital (KR)
- South Australian Health and Medical Research Institute (AU)
- Royal Darwin Hospital (AU)
- The Kinghorn Cancer Centre (AU)
- Act Health (AU)
- The University of Adelaide (AU)
Publication Details
- Journal
- Expert Review of Hematology
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1080/17474086.2025.2574716
- Citations
- 1
- Primary Topic
- Bone health and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.05