Assessment of intestinal barrier integrity and associations with innate immune activation and metabolic syndrome in acutely ill, antipsychotic-free schizophrenia patients

Our findings suggest separable gut‑related processes in antipsychotic-free Sz. The apparent LBP elevation was not schizophrenia‑specific; its strong correlations with CRP and neutrophils point to smoking related inflammation rather than a schizophrenia specific effect. Accordingly, prior findings of LBP elevations in Sz likely reflect unaccounted smoking. In contrast, reduced I-FABP, independent of smoking, may indicate epithelial injury. The absent correlation between LBP and I-FABP highlights distinct pathophysiological dimensions of gut dysfunction. Longitudinal studies, ideally spanning prodromal phases and integrating microbiome, dietary, smoking, and permeability assessments, are needed to clarify temporal dynamics and guide stratified treatments.

Authors

Institutions

Publication Details

Journal
Journal of Neuroinflammation
Published
2025-10-13
DOI
https://doi.org/10.1186/s12974-025-03584-3
Primary Topic
Gut microbiota and health
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Assessment of intestinal barrier integrity and associations with innate immune activation and metabolic syndrome in acutely ill, antipsychotic-free schizophrenia patients

Johann Steiner, Katrin Borucki, Kaushiki Mukherjee, Paul C. Guest et al.
Journal of Neuroinflammation
Gut microbiota and health
article

Assessment of intestinal barrier integrity and associations with innate immune activation and metabolic syndrome in acutely ill, antipsychotic-free schizophrenia patients

Johann Steiner, Katrin Borucki, Kaushiki Mukherjee, Paul C. Guest, Alexander Link, Thomas Nickl‐Jockschat, Hans‐Gert Bernstein, Borna Relja, Gabriela Meyer-Lotz, Henrik Dobrowolny, Kolja Schiltz, Markus Nußbaumer, Leon Dudeck, Leila Shokati Asl
article en

Abstract

Our findings suggest separable gut‑related processes in antipsychotic-free Sz. The apparent LBP elevation was not schizophrenia‑specific; its strong correlations with CRP and neutrophils point to smoking related inflammation rather than a schizophrenia specific effect. Accordingly, prior findings of LBP elevations in Sz likely reflect unaccounted smoking. In contrast, reduced I-FABP, independent of smoking, may indicate epithelial injury. The absent correlation between LBP and I-FABP highlights distinct pathophysiological dimensions of gut dysfunction. Longitudinal studies, ideally spanning prodromal phases and integrating microbiome, dietary, smoking, and permeability assessments, are needed to clarify temporal dynamics and guide stratified treatments.

Journal of NeuroinflammationVol. 22(1)
University of Iowa (US), Universidade Estadual de Campinas (UNICAMP) (BR), Universität Ulm (DE), Center for Behavioral Brain Sciences (DE), University Hospital Magdeburg (DE), Ludwig-Maximilians-Universität München (DE), Otto-von-Guericke-Universität Magdeburg (DE)
Openalex Percentile: Top 74%
Gut microbiota and health
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.