Cerebrospinal fluid markers link to synaptic plasticity responses and Alzheimer’s disease genetic pathways
Reduced markers for excitatory signaling in Aβ+/Tau- and increased synaptic plasticity markers in Aβ+/Tau + cases suggest differential but linked processes underlying disease progression and resilience in the groups.
Authors
- Lene Pålhaugen
- Ragnhild Eide Skogseth (ORCID: https://orcid.org/0000-0001-6688-9955)
- Ann Brinkmalm (ORCID: https://orcid.org/0000-0002-7396-3233)
- Panpan You
- Kaj Blennow (ORCID: https://orcid.org/0000-0002-1890-4193)
- Kaja Nordengen (ORCID: https://orcid.org/0000-0002-5897-6394)
- Pieter Jelle Visser (ORCID: https://orcid.org/0000-0001-8008-9727)
- Betty Marije Tijms (ORCID: https://orcid.org/0000-0002-2612-1797)
- Bjørn‐Eivind Kirsebom (ORCID: https://orcid.org/0000-0002-1413-9578)
- Knut Waterloo (ORCID: https://orcid.org/0000-0003-3447-8312)
- Ellen Vromen
- Nikias Siafarikas (ORCID: https://orcid.org/0000-0002-6969-7470)
- Sandra Tecelão
- Dag Aarsland (ORCID: https://orcid.org/0000-0001-6314-216X)
- Atle Bjørnerud (ORCID: https://orcid.org/0000-0002-3486-3141)
- Tormod Fladby (ORCID: https://orcid.org/0000-0002-9984-9797)
- Gøril Rolfseng Grøntvedt (ORCID: https://orcid.org/0000-0003-2057-6683)
- Johanna Nilsson (ORCID: https://orcid.org/0000-0002-2856-6060)
- Geir Bråthen (ORCID: https://orcid.org/0000-0003-3224-7983)
- Jonas Alexander Jarholm
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Per Selnes (ORCID: https://orcid.org/0000-0001-5131-9757)
- Peter Mikael Arnesen
Institutions
- University of Science and Technology of China (CN)
- Oslo University Hospital (NO)
- University Hospital of North Norway (NO)
- University of Wisconsin–Madison (US)
- King's College London (GB)
- University of Oslo (NO)
- Norwegian University of Science and Technology (NO)
- Stavanger University Hospital (NO)
- Akershus University Hospital (NO)
- Sahlgrenska University Hospital (SE)
- Sorbonne Université (FR)
- Deaconess Hospital (US)
- St Olav's University Hospital (NO)
- Amsterdam Neuroscience (NL)
- Pitié-Salpêtrière Hospital (FR)
- UK Dementia Research Institute (GB)
- Institut du Cerveau (FR)
- University of Bergen (NO)
- University College London (GB)
- UiT The Arctic University of Norway (NO)
- Vrije Universiteit Amsterdam (NL)
- University of Gothenburg (SE)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1186/s13024-025-00899-w
- Citations
- 2
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Familjen Erling-Perssons Stiftelse
- Cure Alzheimer's Fund
- Stiftelsen för Gamla Tjänarinnor
- EU Joint Programme – Neurodegenerative Disease Research
- National Institute for Health and Care Research
- University College London
- European Commission
- Hjärnfonden
- UK Dementia Research Institute
- HORIZON EUROPE Framework Programme