Clinical characteristics and etiology-specific outcome in pediatric hypertrophic cardiomyopathy
The results of this analysis show significant variability of outcomes by HCM subtype in children. Idiopathic/sarcomeric and neuromuscular disease-associated HCM had the best prognosis, while other non-idiopathic/non-sarcomeric forms of HCM showed worse outcomes. Pediatric HCM presents with diverse underlying causes, unique phenotypes, and clinical trajectories, requiring tailored treatment approaches.
Authors
- Norbert Frey (ORCID: https://orcid.org/0000-0001-7611-378X)
- Christoph P. Hofmann (ORCID: https://orcid.org/0000-0002-3389-6582)
- Mirko Völkers (ORCID: https://orcid.org/0000-0003-2344-1856)
- Angela Merzweiler (ORCID: https://orcid.org/0000-0001-5895-7751)
- Sebastian Burkart (ORCID: https://orcid.org/0000-0002-4135-066X)
- Maximilian Klass
- Norman L. Meyer
- Matthias Gorenflo (ORCID: https://orcid.org/0000-0002-3326-5959)
- Maja Hempel (ORCID: https://orcid.org/0000-0003-0609-2738)
- Alexander Kovacevic
- Felix Minette
Institutions
- Harvard University (US)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- German Center for Infection Research (DE)
- German Centre for Cardiovascular Research (DE)
Publication Details
- Journal
- Clinical Research in Cardiology
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1007/s00392-025-02703-7
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Boehringer Ingelheim Stiftung
- Deutsche Gesellschaft für Kardiologie-Herz und Kreislaufforschung.
- Dr. Rolf M. Schwiete Stiftung