Colonization by Akkermansia muciniphila modulates central nervous system autoimmunity in an ecological context-dependent manner
Taken together, our data suggest that the effect of <i>A. muciniphila</i> on CNS autoimmunity is highly dependent on the overall composition of the gut microbiome and suggest that this microbe may contribute to decreased gut SCFA metabolism in multiple sclerosis.
Authors
- Dimitry N. Krementsov (ORCID: https://orcid.org/0000-0003-2709-7466)
- Matthew Scarborough (ORCID: https://orcid.org/0000-0001-8027-7349)
- M. Lee (ORCID: https://orcid.org/0000-0002-9804-3193)
- Lucinda C. Toppen (ORCID: https://orcid.org/0009-0006-5079-4656)
- Daniel Peipert
- Theresa L. Montgomery
Institutions
- University of Vermont (US)
- Vermont Department of Health (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-13
- DOI
- https://doi.org/10.3389/fimmu.2025.1655428
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81