Integration of Dose Surface Maps and Genetic Data Identifies the Lower Posterior Rectum as a Key Region for Toxicity after Prostate Cancer Radiotherapy
This study identified genotype-driven toxicity patterns using spatial dose mapping. By revealing consistent high-risk rectal regions, this approach strengthens the link between genomics and radiotherapy planning. Importantly, modern radiotherapy planning makes it feasible to reduce dose in genetically sensitive patients and move toward more personalized treatment.
Authors
- Jane Shortall (ORCID: https://orcid.org/0000-0002-9672-7671)
- Marcel van Herk (ORCID: https://orcid.org/0000-0001-6448-898X)
- Eliana Vásquez Osorio (ORCID: https://orcid.org/0000-0003-0741-994X)
- Alan McWilliam (ORCID: https://orcid.org/0000-0002-7344-2868)
- Chris J. Talbot (ORCID: https://orcid.org/0000-0001-7406-8962)
- B. Avuzzi (ORCID: https://orcid.org/0000-0002-7135-4506)
- Jenny Chang‐Claude (ORCID: https://orcid.org/0000-0001-8919-1971)
- Adam Webb (ORCID: https://orcid.org/0000-0002-6699-0479)
- Ana Vega (ORCID: https://orcid.org/0000-0002-7416-5137)
- Liv Veldeman (ORCID: https://orcid.org/0000-0002-0995-2687)
- D. Azria (ORCID: https://orcid.org/0000-0002-7533-2988)
- Barry S. Rosenstein (ORCID: https://orcid.org/0000-0002-3149-3237)
- Alison M. Dunning (ORCID: https://orcid.org/0000-0001-6651-7166)
- Eliana Gioscio (ORCID: https://orcid.org/0009-0007-8692-7593)
- Ananya Choudhury (ORCID: https://orcid.org/0000-0002-3561-6580)
- T. Rancati (ORCID: https://orcid.org/0000-0002-7849-603X)
- Dirk De Ruysscher (ORCID: https://orcid.org/0000-0001-9269-6567)
- Maarten Lambrecht (ORCID: https://orcid.org/0000-0002-8746-2691)
- Petra Seibold (ORCID: https://orcid.org/0000-0001-7360-6335)
- Catharine West (ORCID: https://orcid.org/0000-0002-0839-3449)
- Marie‐Pierre Farcy‐Jacquet (ORCID: https://orcid.org/0009-0001-1472-2579)
- Elena Sperk (ORCID: https://orcid.org/0000-0002-8771-8124)
- Sarah L. Kerns (ORCID: https://orcid.org/0000-0002-6503-0011)
- Andrew P. Morris (ORCID: https://orcid.org/0000-0002-6805-6014)
- Artemis Bouzaki (ORCID: https://orcid.org/0009-0002-2222-6687)
Institutions
- HOGENT University of Applied Sciences and Arts (BE)
- University of Leicester (GB)
- Inserm (FR)
- Universität Hamburg (DE)
- German Cancer Research Center (DE)
- Université de Montpellier (FR)
- Medical College of Wisconsin (US)
- Heidelberg University (DE)
- University of Cambridge (GB)
- Universitair Ziekenhuis Leuven (BE)
- Ghent University Hospital (BE)
- University Hospital Heidelberg (DE)
- University of Manchester (GB)
- Ghent University (BE)
- Cancer Research UK Cambridge Center (GB)
- Institut universitaire du cancer de Toulouse Oncopole (FR)
- University Medical Center Hamburg-Eppendorf (DE)
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Institut de Cancérologie de Bourgogne (FR)
- Arthritis UK (GB)
- Fundación Pública Galega de Medicina Xenómica (ES)
- University Cancer Center Hamburg (DE)
- Cancer Research UK Manchester Institute (GB)
- The Christie NHS Foundation Trust (GB)
- Institut de Recherche en Cancérologie de Montpellier (FR)
- Instituto de Investigación Sanitaria de Santiago (ES)
- University Medical Centre Mannheim (DE)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- MRC Epidemiology Unit (GB)
- Maastro Clinic (NL)
- Icahn School of Medicine at Mount Sinai (US)
- KU Leuven (BE)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-2102
- Citations
- 1
- Primary Topic
- Advanced Radiotherapy Techniques
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- Fundación Cellex
- Pancreatic Cancer UK
- Centres de Recerca de Catalunya
- Cancer Research UK
- National Institute for Health and Care Research
- Prostate Cancer UK
- European Commission
- Generalitat de Catalunya
- Vedecká Grantová Agentúra MŠVVaŠ SR a SAV
- Cancer Research UK Manchester Centre
- National Institutes of Health
- Manchester Biomedical Research Centre
- Instituto de Salud Carlos III
- Agencia Estatal de Investigación
- NIHR Leicester Biomedical Research Centre