Liquid Biopsy Identifies Taxane Resistance and Clonal Selection in Castration-Resistant Prostate Cancer
Sequential liquid biopsy identifies ctDNA features associated with treatment benefit in patients with metastatic castration-resistant prostate cancer treated with cabazitaxel. There was overlap of gene alterations selected for at progression on docetaxel or cabazitaxel, in part explaining cross-resistance.
Authors
- Gerhardt Attard (ORCID: https://orcid.org/0000-0002-4811-7983)
- Francesco Orlando (ORCID: https://orcid.org/0000-0001-9884-9413)
- Paolo Cremaschi (ORCID: https://orcid.org/0000-0001-5349-4188)
- Francesco Pierantoni (ORCID: https://orcid.org/0000-0002-8483-0196)
- Yari Ciani (ORCID: https://orcid.org/0000-0002-9635-2830)
- Osvaldas Vainauskas (ORCID: https://orcid.org/0009-0005-2060-7007)
- Anna Wingate (ORCID: https://orcid.org/0009-0008-4965-7093)
- Cristian Lolli (ORCID: https://orcid.org/0000-0003-0347-9179)
- Giuseppe Luigi Banna (ORCID: https://orcid.org/0000-0003-0764-3650)
- Vincenza Conteduca (ORCID: https://orcid.org/0000-0002-6921-714X)
- Maurizio Nicodemo (ORCID: https://orcid.org/0000-0002-5825-0171)
- Giorgia Gurioli (ORCID: https://orcid.org/0000-0003-4036-5568)
- Paola Ulivi (ORCID: https://orcid.org/0000-0002-4334-9662)
- Alessandra Mosca (ORCID: https://orcid.org/0000-0003-2538-8411)
- Francesca Demichelis (ORCID: https://orcid.org/0000-0002-8266-8631)
- Ugo De Giorgi (ORCID: https://orcid.org/0000-0001-7520-2908)
- Sara Bleve (ORCID: https://orcid.org/0009-0008-2704-1423)
- Nicole Brighi (ORCID: https://orcid.org/0000-0002-1187-5481)
- Giuseppe Fornarini (ORCID: https://orcid.org/0000-0003-4754-6572)
- Umberto Basso (ORCID: https://orcid.org/0000-0002-5075-2177)
- Emilio Francesco Giunta (ORCID: https://orcid.org/0000-0002-5383-4469)
- Daniel Wetterskog (ORCID: https://orcid.org/0000-0003-4163-6438)
- Chiara Casadei (ORCID: https://orcid.org/0000-0003-2467-749X)
Institutions
- University of Foggia (IT)
- University of Trento (IT)
- Ospedale San Paolo (IT)
- London Cancer (GB)
- Portsmouth Hospitals NHS Trust (GB)
- Ospedali Riuniti di Foggia (IT)
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IT)
- Ospedale Sacro Cuore Don Calabria (IT)
- Istituto Oncologico Veneto (IT)
- Ospedale Policlinico San Martino (IT)
- CRUK Lung Cancer Centre of Excellence (GB)
- Candiolo Cancer Institute (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University College London (GB)
- University of Portsmouth (GB)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-2121
- Citations
- 1
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52