Off-label drug use in children and adolescents treated with antidepressants and antipsychotics: results from a prospective multicenter trial
The frequency of off-label use of antidepressants and even more of antipsychotics in youths treated at specialized child psychiatric centers is high. As the clinical efficacy and safety of off-label antidepressant and antipsychotic use in youth is under-researched, our results call for further pharmacovigilance studies and strategies to improve drug safety.
Authors
- Hartmut Imgart (ORCID: https://orcid.org/0000-0002-3997-0376)
- Marcel Romanos (ORCID: https://orcid.org/0000-0001-7628-8299)
- Michael Kaess (ORCID: https://orcid.org/0000-0003-0031-7764)
- Paul L. Plener (ORCID: https://orcid.org/0000-0003-4333-1494)
- Peter U. Heuschmann (ORCID: https://orcid.org/0000-0002-2681-3515)
- Andreas Karwautz (ORCID: https://orcid.org/0000-0001-9053-998X)
- Alexander Häge (ORCID: https://orcid.org/0000-0002-3434-2995)
- Christian Rexroth (ORCID: https://orcid.org/0009-0007-4562-0894)
- Su-Yin Reuter-Dang
- Christoph Ulrich Correll (ORCID: https://orcid.org/0000-0002-7254-5646)
- Gerd Schulte‐Körne (ORCID: https://orcid.org/0000-0002-9960-1572)
- Karl Reitzle
- Uwe Malzahn
- Karin Egberts (ORCID: https://orcid.org/0000-0002-0270-0954)
- Christian Fleischhaker (ORCID: https://orcid.org/0000-0002-4167-0014)
- Tobias Hellenschmidt
- Elvira Tini
- Stefanie Fekete (ORCID: https://orcid.org/0000-0003-1925-6228)
- Wolfgang Carl Briegel (ORCID: https://orcid.org/0000-0002-8253-5070)
- Michael Kölch (ORCID: https://orcid.org/0000-0003-2878-5121)
- Hans Rock
- Regina Taurines (ORCID: https://orcid.org/0000-0002-8704-1424)
- Tobias Renner (ORCID: https://orcid.org/0000-0002-2151-9480)
- Maike Scherf‐Clavel (ORCID: https://orcid.org/0000-0002-4780-612X)
- Christoph Wewetzer
- Frank Theisen
- Manfred Gerlach
Institutions
- University of Bern (CH)
- Philipps University of Marburg (DE)
- Zimmer Biomet (Netherlands) (NL)
- Bielefeld University (DE)
- Heidelberg University (DE)
- University of Würzburg (DE)
- University Medical Center Freiburg (DE)
- University Hospital Heidelberg (DE)
- University Hospital Regensburg (DE)
- German Center for Pediatric and Adolescent Rheumatology (DE)
- University Hospital of Zurich (CH)
- Central Institute of Mental Health (DE)
- Donald & Barbara Zucker School of Medicine at Hofstra/Northwell (US)
- Leopoldina Krankenhaus Schweinfurt (DE)
- Vivantes Klinikum (DE)
- German Center for Infection Research (DE)
- Klinik für Psychosomatik (DE)
- Universitätsklinikum Würzburg (DE)
- Social Neuroscience Lab (DE)
- German Centre for Cardiovascular Research (DE)
- Medizinische Hochschule Brandenburg Theodor Fontane (DE)
- University Hospital Cologne (DE)
- University Hospital Ulm (DE)
- Klinikum Fulda (DE)
- Zucker Hillside Hospital (US)
- University of Rostock (DE)
- Medical University of Vienna (AT)
- Charité - Universitätsmedizin Berlin (DE)
- University of Tübingen (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Child and Adolescent Psychiatry and Mental Health
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1186/s13034-025-00957-7
- Citations
- 3
- Primary Topic
- Pharmaceutical studies and practices
- Type
- article
- Field-Weighted Citation Impact
- 10.48