Association between pro-inflammatory proteins and neurofilament in plasma from persons with epilepsy
Inflammation and neurodegeneration are not necessarily linked in all epilepsy patients, but both are more likely to exist in the subset of cases with many seizures. Conversely, absence of both processes indicates well-controlled epilepsy. The combination of plasma NEFL with inflammatory markers could improve seizure prediction and provide novel insights for personalized epilepsy management.
Authors
- Johan Zelano (ORCID: https://orcid.org/0000-0001-9445-4545)
- Markus Axelsson (ORCID: https://orcid.org/0000-0003-2036-4007)
- Sarah Akel (ORCID: https://orcid.org/0000-0003-3806-8724)
- Mayuresh Anant Sarangdhar (ORCID: https://orcid.org/0000-0001-5653-8991)
- Saman Hosseini Ashtiani
Institutions
- Sahlgrenska University Hospital (SE)
- Wallenberg Wood Science Center (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1186/s12916-025-04425-z
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science for Life Laboratory