Spatial immunoprofiling of retroperitoneal leiomyosarcomas reveals intratumoral heterogeneity in immune cell infiltration, checkpoint molecule expression, and tertiary lymphoid structures
These findings highlight substantial intratumoral heterogeneity, which may contribute to the variable response to ICI therapy. As immune checkpoint molecule expression influences treatment eligibility, multiple biopsies from different tumour regions may be necessary to assess immune infiltration accurately and guide therapy decisions.
Authors
- Yvonne Schrage (ORCID: https://orcid.org/0000-0001-7065-514X)
- David S. Moura (ORCID: https://orcid.org/0000-0002-6514-2419)
- Jiřina Bartůňková (ORCID: https://orcid.org/0000-0002-1754-2979)
- Javier Martín‐Broto (ORCID: https://orcid.org/0000-0001-7350-6916)
- Andrej Ozaniak (ORCID: https://orcid.org/0000-0002-4205-2322)
- Kateřina Kopečková (ORCID: https://orcid.org/0000-0002-1907-163X)
- Winan J. van Houdt (ORCID: https://orcid.org/0000-0002-2303-3468)
- Iva Benešová (ORCID: https://orcid.org/0000-0003-4886-4214)
- Zuzana Střížová (ORCID: https://orcid.org/0000-0003-4976-9534)
- Robert Lischke (ORCID: https://orcid.org/0000-0002-0578-1833)
- Michal Rataj
- Ján Balko (ORCID: https://orcid.org/0000-0003-0451-2786)
- Tomáš Büchler (ORCID: https://orcid.org/0000-0001-6667-994X)
- Vira Tovazhnianska
Institutions
- Charles University (CZ)
- University Hospital in Motol (CZ)
- Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (NL)
- Hospital Universitario Fundación Jiménez Díaz (ES)
- General University Hospital in Prague (CZ)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1080/07853890.2025.2568725
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00