NsrM (All0345) and NsrX (Alr1976), two FurC (PerR)-targeted transcriptional regulators, modulate nitrogen metabolism and heterocyst differentiation genes in the cyanobacterium <i>Anabaena</i> sp. strain PCC 7120
Filamentous, nitrogen-fixing cyanobacteria are valuable organisms for biotechnology applications and as models for the study of multicellularity in prokaryotes. Understanding the regulation of nitrogen fixation and heterocyst development is essential for optimizing their use in synthetic biology and as biofertilizers. This study identifies two novel nitrogen secondary regulators, Alr1976 (NsrX) and All0345 (NsrM), as part of the intricate regulatory circuit governing nitrogen metabolism in the model cyanobacterium <i>Anabaena</i> sp. strain PCC7120. Genes encoding NsrX and NsrM are regulated by both FurC (PerR) and NtcA, therefore taking part in the NtcA-PerR network that modulates nitrogen metabolism and heterocyst differentiation genes.
Authors
- Emma Sevilla (ORCID: https://orcid.org/0000-0001-6435-3540)
- Marı́a F. Fillat (ORCID: https://orcid.org/0000-0001-8644-4574)
- M. Teresa Bes (ORCID: https://orcid.org/0000-0002-8181-2689)
- Anindita Bandyopadhyay (ORCID: https://orcid.org/0000-0002-5713-6019)
- Jorge Guío (ORCID: https://orcid.org/0000-0002-0474-255X)
- Himadri B. Pakrasi (ORCID: https://orcid.org/0000-0001-8240-2123)
- Isabelle Michaud‐Soret (ORCID: https://orcid.org/0000-0002-8936-4964)
- Deng Liu (ORCID: https://orcid.org/0000-0002-9211-9863)
- Marta Acero
Institutions
- Washington University in St. Louis (US)
- Universidad de Zaragoza (ES)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- CEA Grenoble (FR)
- Institut de Recherche Interdisciplinaire de Grenoble (FR)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1128/spectrum.02311-25
- Citations
- 2
- Primary Topic
- Photosynthetic Processes and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- U.S. Department of Energy
- Ministerio de Ciencia, Innovación y Universidades
- Gobierno de Aragón
- Office of Science