Pediatric Stevens–Johnson syndrome and toxic epidermal necrolysis: age-stratified insights from the FAERS database
The study reveals clear age- and drug-specific patterns in pediatric SJS/TEN. Findings emphasize the importance of age-stratified pharmacovigilance issues and cautious prescribing of high-risk drugs such as lamotrigine and antibiotics. Better awareness of potential biases, such as protopathic misattribution, is crucial for accurate signal detection in pediatric pharmacovigilance.
Authors
- Onur Gültekin (ORCID: https://orcid.org/0000-0002-0836-076X)
- Ahmet Akıcı (ORCID: https://orcid.org/0000-0002-8593-0818)
- Narin Akıcı (ORCID: https://orcid.org/0000-0002-0600-8631)
- Zehra Esra Önal (ORCID: https://orcid.org/0000-0003-0974-1756)
- Dilara Bayram-Ozgur
- Onur Colak (ORCID: https://orcid.org/0009-0000-9741-3976)
Institutions
- Haydarpaşa Numune Eğitim ve Araştırma Hastanesi (TR)
- Kent Hastanesi (TR)
- Marmara University (TR)
Publication Details
- Journal
- Jornal de Pediatria
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1016/j.jped.2025.101455
- Primary Topic
- Drug-Induced Adverse Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00