Interaction between tumor-infiltrating lymphocytes and BMI in early HER2-positive breast cancer: analysis of the ShortHER trial

We suggest that BMI may impair the local, but not distant, protective effect of TILs in patients with overweight or obesity with HER2-positive eBC treated with adjuvant chemotherapy + trastuzumab.

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Publication Details

Journal
ESMO Open
Published
2025-10-11
DOI
https://doi.org/10.1016/j.esmoop.2025.105832
Primary Topic
Cancer Risks and Factors
Type
article
Field-Weighted Citation Impact
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article

Interaction between tumor-infiltrating lymphocytes and BMI in early HER2-positive breast cancer: analysis of the ShortHER trial

Katia Cagossi, Anita Rimanti, Federica Miglietta, Roberto D’Amico et al.
ESMO Open
Cancer Risks and Factors
article

Interaction between tumor-infiltrating lymphocytes and BMI in early HER2-positive breast cancer: analysis of the ShortHER trial

Katia Cagossi, Anita Rimanti, Federica Miglietta, Roberto D’Amico, Melinda E. Sanders, O Garrone, Samanta Sarti, Stefania Bartolini, Pierfranco Conté, Sara Balduzzi, Giancarlo Bisagni, Antonino Musolino, V Guarneri, Enrico Orvieto, Luigi Cavanna, Maria Vittoria Dieci, Federico Piacentini, Antonella Ferro, Elena Bertone, Francesco Giotta
article en

Abstract

We suggest that BMI may impair the local, but not distant, protective effect of TILs in patients with overweight or obesity with HER2-positive eBC treated with adjuvant chemotherapy + trastuzumab.

ESMO OpenVol. 10(11)
University of Modena and Reggio Emilia (IT), University of Padua (IT), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT), Ospedale Santa Chiara (IT), Azienda Unita' Sanitaria Locale Di Modena (IT), Istituto Ramazzini (IT), AULSS 2 Marca Trevigiana (IT), Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IT), Ospedale Sant'Anna (IT), Azienda Ospedaliero-Universitaria di Modena (IT), Istituto Oncologico Veneto (IT), Istituto delle Scienze Neurologiche di Bologna (IT), Istituto Tumori Bari (IT), Ospedaliera di Piacenza (IT), Istituti di Ricovero e Cura a Carattere Scientifico (IT), Azienda Ospedaliera Carlo Poma (IT), Vanderbilt University Medical Center (US)
Openalex Percentile: Top 61%
Cancer Risks and Factors
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