Interaction between tumor-infiltrating lymphocytes and BMI in early HER2-positive breast cancer: analysis of the ShortHER trial
We suggest that BMI may impair the local, but not distant, protective effect of TILs in patients with overweight or obesity with HER2-positive eBC treated with adjuvant chemotherapy + trastuzumab.
Authors
- Katia Cagossi
- Anita Rimanti
- Federica Miglietta (ORCID: https://orcid.org/0000-0001-6203-874X)
- Roberto D’Amico (ORCID: https://orcid.org/0000-0002-3211-6687)
- Melinda E. Sanders (ORCID: https://orcid.org/0000-0001-7227-1764)
- O Garrone
- Samanta Sarti (ORCID: https://orcid.org/0000-0002-2177-6567)
- Stefania Bartolini (ORCID: https://orcid.org/0000-0003-1255-0109)
- Pierfranco Conté (ORCID: https://orcid.org/0000-0002-5210-5344)
- Sara Balduzzi (ORCID: https://orcid.org/0000-0003-1205-1895)
- Giancarlo Bisagni (ORCID: https://orcid.org/0000-0003-1042-3771)
- Antonino Musolino (ORCID: https://orcid.org/0000-0002-7979-6261)
- V Guarneri
- Enrico Orvieto
- Luigi Cavanna (ORCID: https://orcid.org/0000-0002-0303-3778)
- Maria Vittoria Dieci (ORCID: https://orcid.org/0000-0002-3967-9861)
- Federico Piacentini (ORCID: https://orcid.org/0000-0001-8969-638X)
- Antonella Ferro (ORCID: https://orcid.org/0000-0003-4109-6769)
- Elena Bertone
- Francesco Giotta
Institutions
- University of Modena and Reggio Emilia (IT)
- University of Padua (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Ospedale Santa Chiara (IT)
- Azienda Unita' Sanitaria Locale Di Modena (IT)
- Istituto Ramazzini (IT)
- AULSS 2 Marca Trevigiana (IT)
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IT)
- Ospedale Sant'Anna (IT)
- Azienda Ospedaliero-Universitaria di Modena (IT)
- Istituto Oncologico Veneto (IT)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- Istituto Tumori Bari (IT)
- Ospedaliera di Piacenza (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Azienda Ospedaliera Carlo Poma (IT)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-10-11
- DOI
- https://doi.org/10.1016/j.esmoop.2025.105832
- Primary Topic
- Cancer Risks and Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00