EFFECTIVENESS OF CISSUS QUADRANGULARIS IN ENHANCING THE BONE HEALING PROCESS IN WISTAR RATS

Bone fractures pose significant health concerns in both humans and animals, necessitating effective strategies for accelerated healing. This study is aimed to evaluate the bone healing potential of Cissus quadrangularis (CQ) in Wistar rats. A total of 24 rats were randomly assigned into four groups (n=6 each). Group I served as healthy control, group II as fractured untreated control, group III received oral CQ treatment (400 mg/kg body weight daily for 30 days), and group IV received topical CQ application at the fracture site for the same duration. Biochemical and radiological assessments were conducted to monitor healing progress. Results demonstrated significant (p<0.05) improvements in biochemical markers of bone healing in treated groups compared to the untreated control. Notably, oral administration of CQ in group III showed the most rapid and effective fracture healing, while topical application in group IV also yielded beneficial effects, albeit slightly delayed. In conclusion, Cissus quadrangularis exhibits promising bone-healing properties in Wistar rats, with oral administration proving more effective than topical application. These findings support further investigation into CQ as a natural therapeutic agent for fracture management.