Targeted UDP-glucose ceramide glucosyltransferase stable overexpression induces a metabolic switch improving cell performance at high cell density
These findings highlight crucial metabolic adaptations linked to UGCG expression in production cell lines and underscore the value of carefully controlled UGCG expression levels for optimizing viral vector and VLP manufacturing.
Authors
- Jesús Lavado‐García (ORCID: https://orcid.org/0000-0001-9993-6332)
- Marzia Rahimi
- Lars Keld Nielsen (ORCID: https://orcid.org/0000-0001-8191-3511)
Institutions
- The University of Queensland (AU)
- Novo Nordisk Foundation (DK)
- Technical University of Denmark (DK)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2025-10-13
- DOI
- https://doi.org/10.3389/fbioe.2025.1690203
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Novo Nordisk
- Novo Nordisk Fonden
- H2020 Marie Skłodowska-Curie Actions