Deciphering the cellular tumor microenvironment landscape in salivary gland carcinomas using multiplexed imaging mass cytometry
SDC are characterized by Collagen-/mCAF-rich microenvironments and mCAF-endothelial spatial interactions that are linked to metastasis. ACC display pronounced immune infiltration, suggesting its potential for immunotherapy. mCAFs in SDC emerge as prognostic biomarkers and therapeutic targets, highlighting the importance of targeting CAF-driven metastasis in future treatments. This study provides insights into the biology of SGC and identifies novel prognostic markers.
Authors
- Fengshen Kuo (ORCID: https://orcid.org/0000-0003-1797-2896)
- Lisa Nachtsheim (ORCID: https://orcid.org/0000-0002-0261-4511)
- Alexander Quaas (ORCID: https://orcid.org/0000-0002-9644-2115)
- Marcel Mayer (ORCID: https://orcid.org/0000-0001-9963-1109)
- Christoph Arolt (ORCID: https://orcid.org/0000-0002-6366-2285)
- Alan Loh Ho (ORCID: https://orcid.org/0000-0002-6885-3742)
- Louis Jansen (ORCID: https://orcid.org/0000-0002-3371-7492)
- Marcel Schmiel
- Jens Peter Klußmann (ORCID: https://orcid.org/0000-0002-8223-7954)
- Luc G.T. Morris (ORCID: https://orcid.org/0000-0002-4417-2280)
- Philipp Wolber (ORCID: https://orcid.org/0000-0001-9019-2840)
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- University of Cologne (DE)
- University Hospital Cologne (DE)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1186/s13046-025-03551-z
- Primary Topic
- Salivary Gland Tumors Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Universität zu Köln