Inhibition of CD38 enzyme activity on engrafted human immune cells enhances NAD+ metabolism and inhibits inflammation in an in-vivo model of xeno-GvHD
CD38 positive T cells regulate NAD+ metabolism in inflamed tissues and blockade of CD38 enzyme activity by TNB-738 could represent a novel class of therapeutics for the treatment of inflammatory conditions, including GvHD.
Authors
- Suhasini Iyer (ORCID: https://orcid.org/0009-0004-0835-5161)
- Ben Buelow (ORCID: https://orcid.org/0000-0003-2422-7472)
- Giulia Castello (ORCID: https://orcid.org/0000-0002-5647-178X)
- Wim van Schooten
- Pranjali Dalvi (ORCID: https://orcid.org/0000-0002-5247-9645)
- Eduardo N. Chini (ORCID: https://orcid.org/0000-0003-1555-4834)
- James P. Allison (ORCID: https://orcid.org/0000-0001-8980-5697)
- M. C. Cuturi
- Roland Buelow
- Ute Schellenberger (ORCID: https://orcid.org/0000-0002-4809-9383)
- Laure-Hélène Ouisse
- Harshad S. Ugamraj
- Kevin Dang (ORCID: https://orcid.org/0000-0001-5695-926X)
- Bruce R. Blazar
- Ghenima Ahmil-Boiteau
Institutions
- Inserm (FR)
- Jacksonville College (US)
- University of Minnesota Medical Center (US)
- Mayo Clinic in Florida (US)
- Nantes Université (FR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-13
- DOI
- https://doi.org/10.3389/fimmu.2025.1640611
- Citations
- 1
- Primary Topic
- Calcium signaling and nucleotide metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.12