Cobalt-Catalyzed Enantioselective Arylation of Isatin Derivatives with Arylboronic Acids
Catalytic enantioselective arylation of disubstituted isatin derivatives with easily accessible arylboronic acids promoted by a chiral phosphine-Co complex is presented. Such a process represents an unprecedented Co-catalyzed approach for direct introduction of a variety of aryl groups onto the isatin derivative motif, affording a range of synthetically useful chiral tertiary alcohols in up to 98% yield with 98:2 er.
Authors
- Wenxin Lu (ORCID: https://orcid.org/0000-0001-6388-7743)
- Xing‐Wang Wang (ORCID: https://orcid.org/0000-0002-6004-8458)
- Xiang Xu (ORCID: https://orcid.org/0000-0002-0736-4769)
- Zhihan Zhang (ORCID: https://orcid.org/0000-0002-1758-3914)
- Fanke Meng (ORCID: https://orcid.org/0000-0003-1009-631X)
- Qinglei Chong
Institutions
- Chinese Academy of Sciences (CN)
- Purdue University West Lafayette (US)
- Soochow University (CN)
- Central China Normal University (CN)
- Shanghai Institute of Organic Chemistry (CN)
- Beijing National Laboratory for Molecular Sciences (CN)
- Laboratoire de Synthèse Organique (FR)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1021/acs.joc.5c01349
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.94