Tenecteplase for Acute Ischemic Stroke at 4.5 to 24 Hours: A Meta-Analysis of Randomized Controlled Trials
TNK improves excellent functional outcomes and recanalization in patients with acute ischemic stroke treated within 4.5 to 24 hours, without increasing the risks of symptomatic intracerebral hemorrhage or mortality. Notably, extended-window TNK provides greater additional benefits when EVT is inaccessible, establishing its role as an alternative reperfusion strategy in resource-limited settings.
Authors
- Bo-Yi Yuan
- Zixin Wang (ORCID: https://orcid.org/0000-0001-6713-8299)
- Qingfeng Ma (ORCID: https://orcid.org/0000-0002-0114-6402)
- Xiaonan Wang (ORCID: https://orcid.org/0000-0001-9775-2417)
- Jiamin Li (ORCID: https://orcid.org/0009-0003-1157-9177)
- Jiameng Li (ORCID: https://orcid.org/0000-0002-3652-8849)
Institutions
- Capital Medical University (CN)
- Lithuanian Ornithological Society (LT)
Publication Details
- Journal
- Stroke
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1161/strokeaha.125.053256
- Citations
- 7
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 9.48