Revisiting ‘hot cross bun’ sign: a multicentre MRI study of 97 patients with autopsy-confirmed multiple system atrophy
Grade 1 or 2 HCBS is a highly sensitive finding in patients with MSA-C, and the observation of grade 2 HCBS within 3 years of motor symptom onset has excellent specificity for discriminating MSA-C from SCA, especially when accompanied by MCP hyperintensities.
Authors
- Kentarō Hayashi (ORCID: https://orcid.org/0000-0001-8360-7630)
- Dennis W. Dickson (ORCID: https://orcid.org/0000-0001-7189-7917)
- Satoshi Kuwabara (ORCID: https://orcid.org/0000-0002-4716-8578)
- Shunsuke Koga (ORCID: https://orcid.org/0000-0001-8868-9700)
- Yuichi Riku (ORCID: https://orcid.org/0000-0002-6493-8976)
- Keizo Yasui
- Mari Yoshida (ORCID: https://orcid.org/0000-0002-8520-6184)
- Hajime Yokota (ORCID: https://orcid.org/0000-0003-2389-0299)
- Takashi Ando (ORCID: https://orcid.org/0000-0001-7045-7098)
- Erik H. Middlebrooks (ORCID: https://orcid.org/0000-0002-4418-9605)
- Yuji Takahashi (ORCID: https://orcid.org/0000-0001-5335-7757)
- Masashi Mizutani (ORCID: https://orcid.org/0000-0002-2714-8510)
- Atsuhiko Sugiyama (ORCID: https://orcid.org/0000-0003-0705-9892)
- Hiroki Mukai (ORCID: https://orcid.org/0000-0003-3498-2949)
- Yasushi Iwasaki (ORCID: https://orcid.org/0000-0002-0059-3104)
- Shigeki Hirano (ORCID: https://orcid.org/0000-0003-3473-2317)
- Ban Mihara (ORCID: https://orcid.org/0000-0002-4613-3090)
- Yasuhiro Ito (ORCID: https://orcid.org/0000-0002-7854-0360)
- Hiroaki Sekiya (ORCID: https://orcid.org/0000-0001-9683-5966)
- Terunori Sano (ORCID: https://orcid.org/0000-0001-8967-5984)
- Takahiro Takeda (ORCID: https://orcid.org/0000-0002-9095-3387)
- Masaki Takao (ORCID: https://orcid.org/0000-0002-5392-996X)
- Noriko Sato (ORCID: https://orcid.org/0000-0002-9305-7131)
- Takashi Komori (ORCID: https://orcid.org/0000-0003-3778-2993)
- Takuya Tamura
Institutions
- Chiba University (JP)
- Aichi Medical University (JP)
- Jacksonville College (US)
- Toyota Memorial Hospital (JP)
- Chiba University Hospital (JP)
- Institute of Brain and Blood Vessels (JP)
- National Center of Neurology and Psychiatry (JP)
- Ichinomiya Municipal City Hospital (JP)
- Chiba East Hospital (JP)
- Tokyo Metropolitan Neurological Hospital (JP)
- Japanese Red Cross Nagoya Daiichi Hospital (JP)
- Chiba Hospital (JP)
- National Hospital Organization (JP)
- Mayo Clinic in Florida (US)
- Japanese Red Cross Nagoya Daini Hospital (JP)
Publication Details
- Journal
- Journal of Neurology Neurosurgery & Psychiatry
- Published
- 2025-10-12
- DOI
- https://doi.org/10.1136/jnnp-2025-336869
- Citations
- 1
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- Japan Agency for Medical Research and Development
- Ichihara International Scholarship Foundation
- National Center of Neurology and Psychiatry
- Japan Society for the Promotion of Science