Lanostane–Meroterpene Conjugates with Unusual Aryl Ether Linkage and a Lanostane Dimer from Artificially Cultivated Fruiting Bodies of <i>Ganoderma</i> cf. <i>hochiminhense</i>

Ten previously undescribed compounds, including eight lanostane-meroterpene conjugates, ganohochimins A-H (<b>1</b>-<b>8</b>), a lanostane dimer, ganohochimate A (<b>9</b>), and a meroterpenoid, fornicin F (<b>10</b>), were isolated from the cultivated mushroom <i>Ganoderma cf. hochiminhense</i>-(strain TBRC-BCC 22084). The 24<i>S</i>-configuration of ganohochimin A (<b>1</b>) was determined by cleavage of the aryl ether under acidic conditions. The structure of ganohochimate A (<b>9</b>) was confirmed by alkaline hydrolysis to cleave into two lanostane units. Ganohochimins exhibited cytotoxicity against NCI-H187 (small-cell lung cancer) cells (IC₅₀ 7.7-33 μM) and noncancerous Vero cells (IC₅₀ 6.3-30 μM).